Glucosamine Dosage, Glucosamine and Chondroitine Dose

Effective glucosamine dosage for osteoarthritis/arthritis/tendenitis cure:

Glucosamine HCl (HCI) dosage: 1500 mg
Glucosamine Sulfate dosage (NaCl): 2000 mg

Recommended daily dosage of glucosamine for therapeutic effect:

Dosage of Glucosamine HCI (HCl): 500 mg
Dosage of Glucosamine Sulfate: 700 mg

Typical dose of glucosamine chondroitin complex is:

for 3 weeks - 2 months: glucosamine 1500 mg and chondroitin 1200 mg
later: 1000 mg glucosamine and 800 mg chondroitin

Those doses are for average body: 80 kg.

Warning: Read drug dosage instructions carefully!

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Glucosamine: end of a discussion?

Osteoarthritis involves a deterioration of the cartilage. This overpowering disease touches a great proportion of the people. Marketed in the United States in the form of complements dietetic, glucosamine could attenuate the pains which are associated for him. But the proof of its effectiveness is long in coming…

Osteoarthritis can be the cause of handicaps and important pains, on the level of the articulations of the nape of the neck, the bottom of the back, the knees, the hips and the fingers. Articulations having undergone a traumatism or too intensive requests, can also be touched. The destruction of the cartilage which plays the part of shock absorbers involves pains very handicapping.

A beneficial action on the long term

Many studies allot to glucosamine a beneficial effect in the treatment of osteoarthritis on the short term. But according to criteria's of the World Health Organization, the studies should last three years to be validated and to evaluate the side effects of this compound on the long term. In a publication of the Newspaper of the Medical American Association (JAMA) 1, the pr. Thimothy Mc Alidon of Boston University reviewed the 15 clinical trials published on the subject. And all or almost seemed to comprise many skews. The first stage thus consisted with the establishment of a comparison between glucosamine and a placebo on the long term.

Belgian scientists have just carried out this first step thanks to a study published in the famous English review The Lancet2. The researchers of the university of Liege divided 212 patients arthrosic in two groups: the first receiving a daily amount of 1.500 Mg sulphates glucosamide during three years and the second receiving only one placebo.

The researchers took then radiographies of the knees of the patients at the time of an effort one year and three years after the beginning of the treatment. They then noted an important reduction of space between the bones of the knee among patients receiving a placebo. This reduction by 0,31 mm testifies to the advance of the disease. In parallel, no reduction of this space could be observed at the people treated with glucosamine. An improvement of 25% of the symptoms was also noted, whereas a light aggravation was noted in the other group.

Results to confirm

Not having shown its effectiveness, glucosamine had not been recorded like a drug by Food and Drug Administration. Thus, it is distributed on the other side of the Atlantic only in the form of food complement. Very popular among the people suffering from osteoarthritis, its sales annually constitute a market of 400 million dollars. In Germany and Italy, it is distributed like drug. In France, the lack of scientific literature valid on the subject had led to the abandonment of this product. This last study should thus less make skeptics unquestionable expert and consequently occasion increase the glucosamine sales. In France, the lack of scientific literature valid on the subject had led to the abandonment of this product.

The hormonal treatment protects the articulations

It was known already that the substitute hormonal therapy (THS) of the menopause could have a protective effect with respect to the osteoporosis. But a new study suggests today that it could also prevent the loss of cartilage which deadens the articulation of the knee, thus preventing the appearance of rheumatic pains.

While following 81 post-menopause women, the Australian researchers found that the users of THS on the long term presented thicker cartilages at the level of the knees compared to those while having never used. The cartilage is the fabric making it possible to deaden the pressures exerted on the bones on the level of the articulations. Thus, osteoarthritis is marked by the disappearance of this shock absorber. The THS could offer a means of protection against this degenerative disease. The researchers of University Monash have even estimated the volume of cartilage among women under THS for 5 years compared to the not-users. The investigators found that on average, the thickness of the cartilage was higher than 8% for the first group.

his protective effect will have to be confirmed by fuller studies. The most waited remains without any doubt the vast international investigation Women Health Initiative led near 10.000 women whose results are awaited for 2004.

Glucosamine HCI (Glucosamine Hydrochloride)

The Glucosamine, a natural amino sugar has been available per decades and it is used to treat osteoartritis. It is used as the base for the synthesis of all proteins and lipids glycosylated, and sugars nitrogen-containing. It is produced by the body human and used like precursor in the molecule formation greater calls glycosaminoglycans that are necessary for the growth and the repair of the cartilage. Glycosaminoglycans is a dominant component of bones, sinews, ligaments and liquids in the joint.

The Glucosamine has three chemical forms: sulphate of glucosamine (glucosamine sulphate), hydrochlorate of glucosamine (glucosamine HCI) and n-acetyl-glucosamine. The hydrochlorate of the Glucosamine is concentrated that the form of sulphate and contains less sodium by effective dose comparativily. It makes important functions in the human body like the chemical decontamination of the liver and the kidney, and the protection of the liver against the inflammation. The hydrochlorate of the Glucosamine is used in the treatment of gastric ulcers, to cure the torn cartilages and to control the growth of cells. This form of Glucosamine is used extensively in the manufacture of antibiotics, against drugs of the cancer and cosmetics. It is prepared synthetic or derived from exoskeletons of marine creatures. The hydrochlorate of the Glucosamine is preferred on form of sulphate of the Glucosamine because he is more effective and less expensive. The reason of its effectiveness is that she is purer. It is near pure 99% and he is very stable.

The sulphate of the Glucosamine is done of hydrochlorate of glucosamine adding sulphate or potassium. This leads to the presence of impurities. Another reason of the preference of hydrochlorate of the Glucosamine is that its use assures the receipt 83 percents from glucosamine to the problematic areas that need the treatment with respect to the form the sulphate that gives only 62 percents. That is to say, you would have to take 1995 milligrams from sulphate of glucosamine to equal the effects of hydrochlorate of glucosamine.

The process of the digestion is also one of the important reasons as far as because hydrochlorate it is preferred on sulphate. The stomach contains the hidroclórico acid that is required for the digestion of the food. When the sulphate of glucosamine enters the stomach that cuts the molecule of sulphate and the molecule of hydrochlorate is united, transforming it with effectiveness into hydrochlorate of glucosamine. Therefore he is recommendable to take the form that is accepted easily and to prevent the undesired salts in your body.

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PS See new blog: Glucosamine Notes